Short description
A comprehensive textbook on the topic, this reorganized new edition examines all aspects of ALS from pathology to patient care, and provides the reader with a ready reference to help with the difficulties in patient diagnosis and treatment.
Long description
Amyotrophic lateral sclerosis (ALS), a slowly progressive disease of variable presentation and rate of progress, has come into the limelight after a century of neglect. Recently, the pace of research has rapidly accelerated, stemming from several parallel lines of research: epidemiology and genetics, neurotrophic factors, exciotoxicity and its integral relation to energy metabolism, free radical homeostasis and its relation to apoptotic cell death, and calcium metabolism and cytoskeletal proteins within the motor neuron. All these factors have led to a surge in interest and understanding regarding therapy, the maintenance of quality of life in the disease, and the ethical issues surrounding the progression of this disease.
Review
'Informative, well written and well edited ... should be considered a true textbook of MND. I would thoroughly recommend it to all neurologists with an interest in the pathogenesis or management of this wretched condition.' - Advances in Clinical Neuroscience & Rehabilitation 'I would recommend that neurosurgeons should read this book.' - British Journal of Neurosurgery