Laboratory Guide to the Methods in Biochemical Genetics

Editor:
Nenad Blau; Marinus Duran
Format:
Hardcover

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Laboratory Guide to the Methods in Biochemical Genetics

Short description

This manual deals specifically with laboratory approaches to diagnosing inborn errors of metabolism. The key feature is that each chapter is sufficiently detailed so that any individual can adopt the described method into their own respective laboratory.

Long description

This manual describes laboratory methodology for diagnosing inborn errors of metabolism. Each chapter is sufficiently detailed so as to be self-contained, thus enabling any individual to adopt the method in their own laboratory and obviating the need for additional methods of references. The book is unique in that it is the first of its kind to be published in the last 15 years, and individual chapters have been developed by experts in the field citing both established and 'cutting-edge' technology. Thus, it is sufficiently up-to-date to be applicable to the field of inborn errors of metabolism for all readers and those interested in laboratory diagnosis.

Product details

Publisher:
Springer
ISBN:
9783540766971
Publication date:
August 2008
Length:
252mm
Width:
191mm
Thickness:
36mm
Weight:
1855g
Edition:
Approx. 650 Pp.
Pages:
886
Illustrations:
130 black & white illustrations, 46 colour illustrations, 113 black & white tables

Table of contents

  • Laboratory Strategies in Biochemical Genetics.- QC and QA in the Biochemical Genetic Laboratory.- Simple Metabolic Screening Tests.- Lactate, Pyruvate, Acetoacetate, and 3-Hydroxybutyrate.- Amino Acids.- Homocysteine, S-adenosylmethionine and S-adenosylhomocysteine.- GABA, Homocarnosine, and b-Alanine.- Pipecolic Acid.- Organic Acids.- Acylcarnitines, Incl. in Vitro Loading Tests.- Plasmologens and Polyunsaturated Fatty Acids.- Very-Long-Chain Fatty Acids and Phytanic Acid.- Oxalate, Glycolate, Glycerate, Sulfate, and Citrate.- Glycerol and Glycerol Phosphates.- Biotinidase.- Mitochondrial Respiratory Chain.- Mucopolysaccharides.- Oligosaccharides.- Sialic Acid.- Glycosphingolipids.- Congential Disorders of Glycosylation.- Enzymes and Metabolites of Carbohydrate Metabolism.- Polyols.-Diagnosis of Inherited Defects of Cholesterol Biosynthesis.- Lipoproteins.- Genetic Disorders of Steroid Metabolism Diagnosed by Mass Spectrometry.- Bile Acids.-Pterins and Related Enzymes.- Biogenic Amines.- Folates.- Screening of Disorders of Purine and Pyrimidine Metabolism Using HPLC-Electrospray Tandem Mass Spectrometry.- Creatine and Metabolites.- Porphyrins,Porphobilinogen, and d-Aminolevuline Acid.- Trimethylaminuria.- A Tandem Mass Spectrometry Primer for Metabolite Disease Detection.- Molecular Genetics: Mutation Analysis in the Diagnosis of Metabolic Disorders.- Index.

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Laboratory Guide to the Methods in Biochemical Genetics

Laboratory Guide to the Methods in Biochemical Genetics

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