While talking to his friend on the phone, Mark Stone hears a cacophony of otherworldy screams. Seconds later, his friend is tragically killed in an accident. After he experiences the screams several more times, each time followed by an untimely death, Mark is compelled to act.
Battling his failure to find the meaning behind the screams and hopefully stop death from calling on its next victim. But when his estranged wife, Cheryl, is kidnapped and makes a desperate plea for help, Mark again hears the eerie screams, this time signifying Cheryl's appointment with death. Thus begins the frantic search to find Cheryl before it's too late.