Miss March tells the story of Eugene (Zach Cregger), a sweet but anxious high-school student, who falls down a flight of stairs, hits his head and goes into a coma. Four years later he awakes only to find out that his once virginal high-school sweetheart, Cindi has since become a Playboy playmate.
That’s all it takes to inspire Eugene and his best friend Tucker (Trevor Moore) to take a cross-country road trip to gate-crash the annual Playboy Party at the mansion, where Eugene hopes to woo Cindi back and Tucker hopes to score a playmate. Donning stolen fireman outfits the two sneak into the party; Eugene starts to look for Cindi while Tucker bumps into his idol, Hugh Hefner.
All sorts of craziness ensues as they try to say out of trouble, all the while having the time of their lives!