Lazy stoner Dale Denton (Seth Rogen) has only one reason to visit his equally lazy dealer Saul Silver (James Franco): to purchase weed, specifically, a rare new strain called Pineapple Express.
But when Dale becomes the only witness to a murder by a crooked cop (Rosie Perez) and the city's most dangerous drug lord (Gary Cole), he panics and dumps his roach of Pineapple Express at the scene. But the weed is so rare that it can be traced back Saul. Dale and Saul have to run for their lives as the bad guys are hot on their trail! All aboard the Pineapple Express.