The story takes place in Limbo City,
a contemporary town secretly controlled from the shadows by powerful demons, manipulating humanity through the comforts of life.
Living on the fringes of the brainwashed society is Dante,
a disenfranchised youth at odds with the demons who constantly hunt him, and have made his life a living hell for as long as he could remember.
Over the course of his battles through the twisted streets of Limbo, Dante is contacted by The Order, a rogue group led by his long-lost brother Vergil, hell-bent on exposing the demons to the world and releasing Limbo City from their clutches.
However, as The Order's principle reason for recruiting Dante is because he alone possesses a particular gene that can be used to combat the demons, he remains wary of Vergil and questions his intentions.
While Dante fights alongside The Order, he will learn of his past and the family he never knew, while coming to grips with the incredible powers that come with being a Son of Sparda.